Infections, and in particular the septic response to infections, are rising at an alarming rate in healthcare settings around the globe. This report examines this trend by analyzing the flow of patients with severe infections leading to sepsis through six top U.S. academic medical centers. Data was gathered through 19 interviews with expert physicians within the disciplines of emergency care, internal medicine, infectious disease and critical care. These experts offer their views on the critical points in the patient pathway and on ways to improve management of these patient populations to reach desired outcomes. Physician insights are presented in a 44-page report and through an integrated patient flow map, showing an illustrated view of patient movements through the common pathways that exist across each of the medical centers for each phase of care: Emergency Department, General Inpatient and Intensive Care Unit. This map highlights common points of decision-making and disease onset or progression.